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Description
TREM2 Recombinant Rabbit mAb (SDT-1724-115)Product Specification Host Rabbit Antigen Trem2 Synonyms Triggering receptor expressed on myeloid cells 2; TREM 2; sTREM2 Immunogen Recombinant Protein Clone Number SDT 1724 115 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against Alpha synuclein, SD9. 5, GFAP, NFL, UCHL1, Tau 441. Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | Trem2 |
| Synonyms | Triggering receptor expressed on myeloid cells 2; TREM-2; sTREM2 |
| Immunogen | Recombinant Protein |
| Clone Number | SDT-1724-115 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against Alpha-synuclein, SD9.5, GFAP, NFL, UCHL1, Tau-441. |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
The transmembrane TREM2 receptor undergoes ectodomain shedding, leading to release of soluble fragments, soluble TREM2 (sTREM2). In the cerebrospinal fluid (CSF) sTREM2 serves as a surrogate measure of microglial activity. The value of CSF or plasma sTREM2 as an AD diagnostic biomarker has been explored in several studies. Most studies show that CSF sTREM2 is increased in the AD continuum, but the results are somewhat inconsistent regarding disease stages. Some studies indicate sTREM2 to increase in the preclinical phase while others find highest sTREM2 levels in the MCI stage of AD, indicating TREM2-related microglia activation in the early clinical stages of the disease. Others report increased levels of sTREM2 in AD dementia, decreased levels of sTREM2 in AD dementia, or no differences along the AD continuum. Furthermore, preclinical and clinical studies indicate that sTREM2 may exert neuroprotective effects by mitigating Aβ and tau pathologies, potentially slowing cognitive decline and disease progression.
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4.4 ★★★★★
Based on 1876 reviews
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Product Reviews
★★★★★ 5
Why didn’t I buy this sooner?
I am so happy I shelled out for the 7602. HP makes less expensive Ink tank printers but this is perfect for me.
Pros:
1. The printing quality is great. I’m in the middle of a massive project that requires thousands of pages to be printed.
I upgraded to 32lb paper to ensure the project would be quality, but also to handle double sided printing with images. The images with this printer and clear with zero smudging.
2. It’s fast.
It said 12 pages per minute, but I’m getting more than that double sided.
3. The paper tray.
The ad doesn’t go into this, but the paper tray is rad. I have terrible back pain so to sit and do a project for hours is hard enough. To have to get up to reload a paper tray sucks. This paper capacity has got to take 200-250 sheets. I grab about half the package of paper to fit a load snuggly. I LOVE this feature.
4. The cost
I was worried about the reality of the savings on ink. The initial cost is over $300. However the little ink jet cartridges are between $30 to $50 each time. They run out so fast. Plus, HP changed the machines to only read their proprietary cartridges, so you can’t order a cheap fast cartridge off Amazon.
I printed close to 1,000 pages last night and I’m only seeing a slight dip in the ink levels. That’s crazy.
Now consider the ink. The bottles are designed so they fit over the loading tube. No mess. I was worried about this because I am a stone cold clutz. I did spill a drop of blue, but I was moving fast. The bottles have a plastic top the presses into the tube creating a seal. Imagine when you pull a gas nozzle out of your tank. If you are in a rush you might drip gas on your car. This is the same. You pull the bottle up slowly allowing the plastic barrier to seal. I just whipped off the bottle but only 1 drop spilled, by the tube.
I haven’t tried the scanner. I will update in awhile.
The only con is the paper catch. This is where the prints come out and stack up. It has a manual slide out. If you forget to pull it out your pages will end up on the floor. I’m a bit spoiled from the automatic arm that extended on my ink jet when you press print.
To me that is such a small sacrifice for all the advantages. I highly recommend this printer. In the last 3 months I spent $600 on cartridges. I wish I had done this sooner!
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Reviewed in the United States on August 31, 2025
★★★★★ 4
So far a great printer
So far a great printer. Was a little worried after reading a lot of the reviews. However I was tired of ink cartridges and wanted to give the tank a shot. Heck I have 30 days to try it out with Amazon returns , so why not.
Setup only took a couple minutes. Simple to read instructions, online setup guides made it quick and easy.
Filling the ink tanks was painless.
Installing printer heads was easy. Although was a little worried as it took a little more force the. Expecting to close the cover. Was afraid I was going to brake it.
Zero problems connecting to internet.
Did a test fax and worked great!
Did a test scan with zero issues!
Printed several test pages from cell phone and computer with zero issues.
Print quality was great even with testing on plain printer paper.
Only negative I have is the power cable does not connect securely and can easily come loose causing power to disconnect. Which is my reason for 4 stars as I can see how this might become an issue
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Reviewed in the United States on April 5, 2026
★★★★★ 5
Very Happy with My New Printer - Features Important to You are Worth the Cost
My HP Photosmart 7520 purchased in Dec 2014 finally died. It was inexpensive, but was a faithful servant! I could not resolve a new "printhead not detected" error and although I may still be able to fix, I thought it time to replace. I grew tired of the print cartridge change outs. I just spent a day using this new (my third HP) printer and all is well. I like everything about it. Ease of set up, the paper tray, document feeder, the look/design, and especially the ink. The ink will last a long time given my use and replacements will not be $$. I even like the panel light which duration can be user selected. I could have spent less, but the additional features are worth the cost to me. The set up via my MacBook was easy. Yes, I could have done this with my phone, but I enjoy using my Mac. Registration was seamless. I did have a hiccup. Initially color printing was not available from my Mac OS. HP test pages were fine, but no color via any apps using my Mac OS. I Googled the issue and within 2 minutes I found that a reinstall of the Mac driver from the HP site was needed. That took another 2 minutes and color options appeared in the print settings! Strange, I know, and I don't care why ... just glad that a fix was that easy. So, I examined Canon, Brother, and all the HP models, chose this one and glad I did. I have been messing with this tech since the late '80s and I like how HP has evolved its printers. My laser printer experience was limited to the workplace ... I am an inkjet guy at home so I limited my search to that format. I don't think you will be disappointed. Purchased via Amazon. Delivery within 2 days.
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Reviewed in the United States on December 24, 2025
★★★★★ 3
good and bad
Good: The ink tank concept is brilliant. It was insanely easy and mess-free to install the print heads and fill the ink tanks. The control panel is elegant and nicely integrated into the printer. The whole thing was relatively easy to set up. The print quality was fine.
Bad: The first printer I received was covered in ink because apparently the black ink exploded in transit. The replacement printer came barely in time. I tried to print Microsoft Word labels from the HP app, and wasted a lot of labels because it refused to format correctly. Then I had trouble printing in color from Microsoft (but at least the formatting matched the labels). After an update, I was able to print labels in color, BUT had to do one sheet at a time because they kept jamming (set at specialty paper glossy since they were glossy labels) -- again wasted a lot of labels. AND it took FOREVER to print one sheet of labels in color, even when there was barely any color. After it jammed, the color on the labels changed and took several sheets to return to the original colors. I donʻt know yet if the print heads were actually damaged, but it seemed to recover eventually
If you want to print a lot of labels in color in a reasonable amount of time without having to feed one sheet at a time, this is not the printer for you. If you mostly print black & white on regular paper, and only occasionally need color, then maybe it will work for you. I havenʻt tried scanning. Again, the ink tank concept is a game changer, but this printer is far from perfect.
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Reviewed in the United States on August 9, 2025
★★★★★ 5
Impressive multi-functional home printer, A++ touch screen
Note: I've used this printer for almost a month so far.
I was very impressed with the unboxing experience of this HP Smart Tank 7600 printer. I had no trouble lifting the printer out of the box, because they actually put it inside a plastic bag with nice handles! It was easy peasy. Everything was nicely labeled and I followed the instructions from the HP Smart app (both on PC and phone) and went through step by step to set up the printer. HP really knocked the basic setup part out of the park with this one. It's the best instructions I have ever seen.
It was super easy filling the ink tanks with the bottles. I was expecting some leakage and had paper towels ready but nope, not a single drop leaked from it during filling! It takes less than 30 seconds for each bottle to finish filling the printer. Impressive. Setting up WiFi was easy and it immediately updated the printer with the latest firmware. This part did take 5-10 minutes but once it was done, I was able to print immediately.
My favorite feature is the matte surface touch screen. It is bright, responsive, and very intuitive to use. Advanced Features: Since this printer had a lot of advanced features, I tried them out. First, I set up the scan to email feature. This took a while to figure out, with the assistance of online help, I was able to configure Gmail's SMTP server to send out printer scans to other emails. This was complicated to use another SMTP server but not the fault of HP. Next, I set up the device to scan to my NAS drive. I had a slight hiccup because I had to fix my NAS account to allow write permission before it started working. Lastly, I discovered it to be faster to enter email contacts through the HP Smart app address book instead of trying to enter them via the printer's touch screen.
The printer itself prints very fast in both color and black and white. While it doesn't quite match the print quality of color laser printers, it's still very impressive for an ink jet printer. Just the fact that the large amount of ink in the tanks versus traditional cartridges or toners will be huge savings for me. The scanning features will make this a lot more useful so I don't need to get another separate scanner. Overall, I really like this printer and it will be my primary family printer from now on.
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Reviewed in the United States on January 16, 2024