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Description
UCP1 Recombinant Rabbit mAb (SDT-2275-37)Product Specification Host Rabbit Antigen UCP1 Synonyms Mitochondrial brown fat uncoupling protein 1; UCP 1 Curated; Solute carrier family 25 member 7; Thermogenin; SLC25A7; UCP Immunogen Synthetic Peptide Location Mitochondrion Accession P25874 Clone Number SDT 2275 37 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms Positive Sample human brown adipose, mouse brown adipose Predicted Reactivity Sq, Hm Purification
Product Specification
| Host | Rabbit |
| Antigen | UCP1 |
| Synonyms | Mitochondrial brown fat uncoupling protein 1; UCP 1 Curated; Solute carrier family 25 member 7; Thermogenin; SLC25A7; UCP |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P25874 |
| Clone Number | SDT-2275-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms |
| Positive Sample | human brown adipose, mouse brown adipose |
| Predicted Reactivity | Sq, Hm |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms |
| IHC-P | 1:250 | Hu, Ms |
| IF | 1:500 | Ms |
Background
UCP1 (uncoupling protein 1), a 33 kDa integral membrane protein located in the inner mitochondrial membrane of brown adipose tissue, operates as a protonophore that dissipates the electrochemical gradient generated by the electron transport chain, thereby uncoupling oxidative phosphorylation from ATP synthesis and converting the released chemical energy into heat (non-shivering thermogenesis); it is activated by cold-induced sympathetic release of norepinephrine via β3-adrenergic receptors, which elevates cAMP and triggers lipolysis, liberating free fatty acids that both allosterically activate UCP1 and serve as respiratory substrates, while purine nucleotides (ATP/ADP) inhibit its activity competitively, and its transcription is synergistically regulated by PGC-1α, PPARγ, and the thyroid hormone T3, making UCP1 a critical determinant of systemic energy expenditure and a promising target for anti-obesity therapeutics.
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