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Description
VGLUT3 Recombinant Rabbit mAb (S-2430-26)Product Specification Host Rabbit Antigen VGLUT3 Synonyms Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8; Slc17a8 Immunogen Recombinant Protein Location Cell membrane, Synapse Accession Q8BFU8 Clone Number S 2430 26 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Positive Sample Mouse hippocampus, mouse brain, rat hippocampus, rat brain Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | VGLUT3 |
| Synonyms | Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8; Slc17a8 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane, Synapse |
| Accession | Q8BFU8 |
| Clone Number | S-2430-26 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Positive Sample | Mouse hippocampus, mouse brain, rat hippocampus, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:250 | Ms |
| IHC-P | 1:500 | Ms, Rt |
Background
VGLUT3 (Vesicular Glutamate Transporter 3) is a 60-kDa multi-pass transmembrane protein encoded by the SLC17A8 gene that packages glutamate into synaptic vesicles for activity-dependent release, but unlike VGLUT1 and VGLUT2 it is expressed primarily in neurons that were traditionally considered non-glutamatergic—such as cholinergic striatal interneurons, serotonergic raphe neurons, and GABAergic interneurons—thereby enabling co-transmission of glutamate with acetylcholine, serotonin, or GABA; VGLUT3 also localizes to the somatodendritic compartment where it can modulate retrograde signaling, and genetic deletion in mice produces auditory neuropathy, social deficits, and altered pain perception, while human SLC17A8 mutations cause progressive sensorineural deafness (DFNA25), collectively illustrating its critical role in diverse circuits ranging from cochlear ribbon synapses to cortico-striatal networks.
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