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Description
Phospho- Zap-70 (Tyr319)/Syk (Tyr352) Recombinant Rabbit mAb (S-1252-12)Product Specification Host Rabbit Antigen Phospho Zap 70 (Tyr319) Syk (Tyr352) Synonyms Tyrosine protein kinase ZAP 70; 70 kDa zeta chain associated protein; Syk related tyrosine kinase; SRK; ZAP70; Tyrosine protein kinase SYK; Spleen tyrosine kinase; p72 Syk; SYK Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane, Synapse Accession P43403 P43405 Clone Number S 1252 12 Antibody Type Recombinant mAb Isotype IgG Application WB,
Product Specification
| Host | Rabbit |
| Antigen | Phospho- Zap-70 (Tyr319)/Syk (Tyr352) |
| Synonyms | Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase; SRK; ZAP70; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk; SYK |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Cell membrane, Synapse |
| Accession | P43403、 P43405 |
| Clone Number | S-1252-12 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:2000 | Hu, Rt |
| ICC | 1:500 | Hu |
Background
Phospho-Zap-70 (Tyr319)/Syk (Tyr352) is the dually phosphorylated, catalytically active form of the tandem SH2-bearing Syk family tyrosine kinases Zap-70 and Syk, wherein phosphorylation of Tyr319 in Zap-70 (or the homologous Tyr352 in Syk) within the interdomain B linker induces an open conformation that relieves autoinhibition, promotes recruitment to doubly phosphorylated ITAM motifs of the T-cell receptor (Zap-70) or B-cell receptor (Syk) signaling complexes, and creates docking sites for downstream adaptors such as LAT and BLNK, thereby propagating calcium flux, MAPK activation, and transcriptional programs essential for lymphocyte development, activation, and effector function.
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4.3 ★★★★★
Based on 1122 reviews
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Product Reviews
★★★★★ 5
The Best!
This thing is amazing! Worked right out of the box. No drivers to install, no confusion, just plug and go. I'm using this hub to connect a mouse, a keyboard, and a monitor to my 2025 MacBook Air (M4).
Before buying this I bought a complicated, powered hub for 2x the price and wasted multiple hours trying to get the $%^&(*& thing to work, which it never did. If you want to run a display and a few peripherals, this Startech hub is the absolute best bang for your buck.
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Reviewed in the United States on December 8, 2025
★★★★★ 1
Quality Control Issues
I want to like this dock, I really do. I purchased it with the intention of using it as a hub for my phone + usb-c external display.
The pass-through charging never worked on this dock. Tried multiple cords and tested the dock with nothing plugged into any of the USB ports -- all of the power disappears somewhere onto the hub and the actual charge rate on my phone slows to a trickle. With nothing connected, it estimates >24hrs to charge from 30% to full.
The plus side is that the usb ports do work, though the usb-c display went from 100% reliability to <50% within a few months of purchase. Extremely frustrating.
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Reviewed in the United States on September 24, 2024
★★★★★ 5
This is the one, buy it for DeX!
Looking for a compact USB hub to connect your laptop or Samsung DeX capable device? Buy this one!
I've tried multiple similar items from name brands, and they work fine as a USB and port hub, but this one is able to support power delivery and display data through a single (capable) USB-c cable. I assume because it is noted to be capable of some combo of USB 3.2, PD 3.0 pass through and DP 1.4 alt mode. I'm not quite sure which one(s) make it possible, but it works for an HP Spectre laptop and Galaxy phone.
Only improvement suggestion is to add an additional 10gb capable USB-C port in place of the three USB-A ports, but that's being super picky.
Thanks StarTech for building another unique solution for connectivity challenges.
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Reviewed in the United States on February 16, 2025
★★★★★ 2
Usb-c passthrough started failing about a year into ownership.
This had the potential to be the perfect accessory for my M4 MacBook Air. It is very difficult to find dongles like this that support display passthrough via usb-c (meaning that if you have a usb-c display you can connect it to this and use the display). When it did work, I was able to power a triple monitor setup with my 2 port Macbook Air (with one display being driven by a displaylink adapter).
If this product had continued to work as advertised, is would be a 5 star review.
But after maybe a year of VERY sporadic use (I use this maybe once a week because my MacBook Air is not often docked) the usb-c passthrough is already failing. On a display I use every day with a different machine (a 16" MBP that has enough ports to not need any adapters) and the display and cable work perfectly fine there so I can only assume that it is this specific adapter which is failing. If I insert the connector several times, sometimes I can get it to work but my success rate just keeps dropping. There was no other reason to spend this much on an adapter that without usb-c passthrough offers just 3 usb-a ports like most much cheaper adapters. So to say I am disappointed is an understatement.
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Reviewed in the United States on May 30, 2026
★★★★★ 4
Expensive, but it works
The good parts:
Yup, this works with DP alt mode, single cable use works for most devices I tried (steam deck, laptop, odin mini 2) even without the hub powered through the power in on the hub, I even got it working without external power to either the hub or my small usb-c monitor. However, some devices like my phone likely didn't give enough power for it to work without another power source. On my phone it worked for some usb devices without external power, but the dp alt mode didn't do work. DP alt on my phone works just fine with external power connected to the hub. Powering it with a small but powerful power bank worked fine, but lower power power banks might not keep up especially if the monitor isn't getting it's own power. It only takes a watt or two of power for the hub itself from some quick and dirty measurements charging my laptop through the pd-in on the hub.
As for the rest of it, the three usb 3 ports means you should be enough to get by for any use case, though you may need more dongles or adapters to get the type of connections you need, but quite usable as-is for a lot of purposes.
Basically it does what it says, there really is no other hub currently that can do pd alt mode, only big docks which need power supplies.
The ok parts:
*When it isn't powered* I noticed that with a monitor already plugged in, plugging it into a device would lead to the monitor not being initialized. But plugging the hub into the device first before connecting the monitor worked. No issue when it was powered. You can use this to get display out and charge with a Nintendo switch, but if it's not powered through the pd-in it probably wont switch to TV mode and output video, not sure if that's because of power or software reasons.
This is a nitpick, but if you care about the feel or aesthetic it's noticeably bland. The case is plastic and there seems to be no weighting on the inside, it's very light, which can feel cheap but it's not like adding weights would functionally make it better, the case also has a bit of a harsh feeling where it's joined, but it does feel solid and durable enough. It's clearly function over form, just barely meets the minimum bar imo.
The bad part:
You already saw, but the price is a bit steep for a hub (at $80). I'd love to see it at 60 or even 40 instead, I hope more similar hubs pop up for competition.
In summary:
It does what it says, if you know you want this and what it is then get it, I feel like it shouldn't cost this much, but it's quite usable and for now it's the only option for a DP alt mode hub.
Minus a half star each for subpar presentation and price 4/5
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Reviewed in the United States on October 4, 2024