Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
IRGQ Recombinant Rabbit mAb (S-2648-17)Product Specification Host Rabbit Antigen IRGQ Synonyms Immunity related GTPase family Q protein; IRGQ1 Immunogen Synthetic Peptide Location Lysosome Accession Q8WZA9 Clone Number S 2648 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Mk Positive Sample RD, SK BR 3, MCF7, BxPC 3, U 2 OS, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | IRGQ |
| Synonyms | Immunity-related GTPase family Q protein; IRGQ1 |
| Immunogen | Synthetic Peptide |
| Location | Lysosome |
| Accession | Q8WZA9 |
| Clone Number | S-2648-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Mk |
| Positive Sample | RD, SK-BR-3, MCF7, BxPC-3, U-2 OS, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
| IHC-P | 1:200 | Hu, Ms |
Background
IRGQ (Immunity-related GTPase family Q protein) is a newly recognized autophagy receptor that orchestrates quality control of MHC class I molecules by binding to the autophagy proteins GABARAPL2 and LC3B, thereby routing misfolded MHC-I heavy chains to lysosomal degradation; its absence allows these defective chains to accumulate and reach the cell surface, enhancing CD8⁺ T cell responses and improving survival in hepatocellular carcinoma models, and IRGQ is also implicated in Alzheime’s pathogenesis and exhibits broad cytoplasmic/nuclear expression across human tissues.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy