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Description
Cytokeratin 6A (KRT6A) Recombinant Mouse mAb (SDT-3380)Product Specification Host Mouse Antigen Cytokeratin 6A (KRT6A) Synonyms Keratin, type II cytoskeletal 6A; Cytokeratin 6A (CK 6A); Cytokeratin 6D (CK 6D); Keratin 6A (K6A); Type II keratin Kb6; Allergen name; Hom s 5; K6A; KRT6D Location Nucleus, Membrane Accession P02538 Clone Number SDT 3380 Antibody Type Mouse mAb Isotype IgG2a,k Application WB, IHC P Reactivity Hu, Ms Positive Sample A431, HaCaT Purification Protein A Concentration 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | Cytokeratin 6A (KRT6A) |
| Synonyms | Keratin, type II cytoskeletal 6A; Cytokeratin-6A (CK-6A); Cytokeratin-6D (CK-6D); Keratin-6A (K6A); Type-II keratin Kb6; Allergen name; Hom s 5; K6A; KRT6D |
| Location | Nucleus, Membrane |
| Accession | P02538 |
| Clone Number | SDT-3380 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | A431, HaCaT |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu |
| IHC-P | 1:1000 | Hu, Ms |
Background
Cytokeratin 6A (KRT6A) is a type II intermediate filament keratin that assembles with its obligatory partner keratin 16 to form robust cytoskeletal networks in stratified epithelia, especially in palmoplantar epidermis and oral mucosa, where it confers mechanical resilience under shear stress; its expression is rapidly up-regulated following injury, inflammation, or hyperproliferation via STAT3, NF-κB and MAPK signaling, and gain-of-function mutations (e.g., p.N171K) cause pachyonychia congenita with thickened nails and painful palmoplantar keratoderma, while loss-of-function variants delay wound closure and attenuate keratinocyte migration, highlighting KRT6A’s dual role in epithelial protection and pathological remodeling.
Shipping Notes
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